response MSG is not a true allergen but may directly affect immune
response by stimulating or damaging the nervous system.
In studies done recently on animals, food allergies may
be caused by a lack of Interleukin 12. This substance is made by cells
in the body - oligodendrocytes, that are killed by excess glutamate.
Also - Over 85% of individuals with Type 1 Diabetes have antibodies to the
enzyme the body uses to turn Glutamate into GABA - glutamic acid decarboxylase
(GAD). Their immune system attacks the means by which glutamate is metabolized, even
though it does not attack glutamate itself. Because of their immune response to GAD,
Type 1 diabetics are at risk of having an excess of glutamate in their systems already.
Pressure - may create taurine deficiency calcium channels stay open
causing high blood pressure and counteracting calcium channel blocking medication.
Glutamate is vasoactive - it changes the diameter of the blood vessels - one reason why it
may cause headaches.
periods of hypoglycemia where low blood glucose levels leave the brain with low defenses,
or allergy response where the blood vessels become "leaky", MSG may cross the
blood brain barrier and damage brain cells by excitatory neurotoxicity. By affecting the
pancreas and creating a situation of hypoglycemia, MSG may bring down the brains
barriers, carrying its own key, in a sense, to get to the brain.
system may create taurine deficiency due to its effect on cysteine.
Cysteine competes with glutamate for uptake. Unfortunately, cysteine is used to make
taurine, and taurine is used to make bile. Bile, which is made by the liver and
stored in the gall bladder is used to break up fats into managable pieces for
digestion. If bile formation is compromised - diarrhea and "gall bladder
attacks" may occur.
Endocrine System -
GABA (gamma amino butyric acid) is created by feedback mechanism from MSG. GABA may be
addictive. Related to the date-rape drug GBH. GABA stimulates the pituitary to produce
growth hormone. Research has shown that MSG can also overstimulate prolactin
production by the pituitary and cause sterility in female animals. Nearly half of
all pituitary tumors are prolactin secreting.
- The hair cells of the ear use glutamate as a neurotransmitter.
Over-stimulation of these cells by glutamate can result in ringing in the ears.
Glutamate opens calcium channels.
Rate - May create taurine deficiency (taurine regulates heartbeat)
causing irregular or racing heartbeat.
MSGs stimulation of pancreas decreases blood glucose, making hypoglycemia
(low blood sugar) worse.
part of the brain most susceptible to attack because it is the "sensor" of the
brain, out in the open so to speak, not protected by the blood brain barrier because it
needs to monitor levels of hormones in the blood. This part of the brain directs the
action of the pituitary gland which directs the action of the entire endocrine system.
Many MSG sensitive persons become diagnosed with thyroid disfunction and are put on
synthetic hormone due to hypothyroidism. This would suggest that the hypothalamus may be
compromised and unable to effectively direct the pituitary gland and consequently the
thyroid. The hypothalamus also regulates hunger, and body temperature. The
hypothalamus is also responsible for rage and panic as well...
Lungs - Asthma - due to MSGs stimulatory effect on the nervous system
(See Johns Hopkins research) would explain why asthma is induced in some by MSG.
Nervous system -
MSG stimulates nerves in tongue and elsewhere directly (thats why they use it).
Glutamate in excess can overstimulate nerve cells until they die.
Certain cells called oligodendrocytes which are found in the nervous
system and make MYELIN are killed by excess glutamate. It is the
inability to make myelin which defines the disease Multiple Sclerosis.
In those patients, Interleukin 12 is low. IL 12 is also made by
the oligodendrocytes - a clue that these cells are probably being killed
by something. We firmly believe that something may be MSG and
aspartame in the diet.
glutamate stimulates the pancreas and may cause Type II diabetes,
obesity, and insulin resistance. In individuals with Type 1 diabetes, it may cause
an excess of glutamate since 85% of those with Type 1 diabetes have antibodies which
attack GAD - the enzyme responsible for converting glutamate into GABA.
See Hypothalamus above
- There are glutamate receptors in the retina. Laboratory studies on animals have
shown the retina to be damaged by MSG.
Food For Thought
American Restaurant Syndrome?
What exactly is MSG?
What Makes Me MSG Sensitive?
Body Systems Affected by MSG
Disease States Affected by MSG
What Foods To Avoid?
What To Eat?
MSG in the NEWS