MSG and Alzheimer's

Beta Amyloid and MSG
According to the following study, beta amyloid protein deposits in the brain seen in Alzheimer's disease actually increase the neurotoxicity of glutamate in the brain:

http://www.jneurosci.org/cgi/content/abstract/12/2/376

This makes the current practice of feeding MSG to elderly patients who are suffering from Alzheimer's disease, tantamount to poisoning them.  Unfortunately, the MSG makers are pushing the use of MSG in nursing homes and in "low sodium" foods fed to the elderly - the every folks who may be suffering end stage Alzheimer's disease.

Glutamate Blocking Drugs

The latest drug reported July 21, 2008 to help with Alzheimer's disease is a 20 year old over-the-counter drug  in Russia used as an anti-histamine.  It is called Dimebon. It is a calcium channel blocker and a neuroprotective glutamate blocker that acts to calm down the nervous system by affecting the NMDA glutamate receptors.  It also appears to have a beneficial effect at the cellular level on mitocondrial pores.

http://www.independent.co.uk/life-style/health-and-wellbeing/features/have-scientists-discovered-a-cure-for-alzheimers-873649.html

The research underway using glutamate blocking drugs for treating Alzheimer's Disease appears to be successful.  The reasoning was that neuron (nerve cell) death is due to the neurotoxic effects of excess glutamate in the brain.  These drugs target the NMDA receptor which is activated by glutamate as well as aspartic acid (found in aspartame).  For more information on glutamate blocker use for Alzheimer's see the following link:

http://www.lundbeck.com/investor/releases/ReleaseDetails/Release_73_EN.asp

Glutamate blocker Memantine is already being used.  See the following link:

http://www.memantine.com/en/mode_of_action/

http://www.newscientist.com/news/news.jsp?id=ns99993586

Inflammation

According to researchers Patrick and Edith McGreer in Vancouver, in the June 2000 issue of Scientific American, anti-inflammatory agents may hold the key to treating Alzheimer's disease.  They believe Alzheimer's disease is "the body's own immune system turning on it". 

Based on this information, it would seem that food ingredients that overstimulate the immune system may spell a problem.  MSG is a nervous system stimulant and according to research by Johns Hopkins announced in May 2000 nervous system hypersensitivity affects the immune system in dramatic ways:

http://www.hopkinsmedicine.org/press/2000/MAY/000518.HTM

Glutamate also increases histamine response as well:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1381677&dopt=Abstract

It makes perfect sense that a drug long known as an anti-histamine would also be helpful in treating Alzheimer's.

Alzheimer's, Obesity, and Stroke

In many recent studies, Alzheimer's disease and obesity, as well as stroke, are turning up in the same patients.  This has led some in the media to jump to the conclusion that obesity, and stroke lead to Alzheimer's.  However, would it not also be valid to conclude that MSG may be responsible for Alzheimer's in those patients that are also obese and have had strokes?  MSG is already implicated in Alzheimer's, obesity, and stroke.  It would make sense that MSG was the cause if someone has all three MSG-induced diseases, would it not?

Insulin

According to this link, researchers have discovered that insulin is related to Alzheimer's disease.  Insulin is produced in the brain as well as in the pancreas.  http://www.news-medical.net/?id=8212

It may not be coincidence that both Alzheimer's and diabetes are both impacted by glutamate.  See our page on MSG and Diabetes. 

 

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MSG and ADD
MSG and Addiction
MSG and Alcoholism
MSG and Allergy
MSG and A.L.S.
MSG and Alzheimer's
MSG and Asthma
MSG and Atrial Fibrillation
MSG and Autism
MSG and Blindness
MSG and Cancer
MSG and Celiac Sprue
MSG and Depression
MSG and Diabetes
MSG and Dizziness
MSG and Epilepsy
MSG and Fibromyalgia
MSG and Heat Stroke
MSG and High Blood Pressure
MSG and Hypoglycemia
MSG and Hypothyroidism
MSG and IBS
MSG and Inflammation
MSG and Migraine
MSG and MS
MSG and Myopia
MSG and Obesity
MSG and Pituitary Tumors
MSG and Rage/Panic Disorder
MSG and Rosacea
MSG and Sulfite Sensitivity
MSG and Tinnitus
MSG and Sleeplessness

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